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目的对人类免疫缺陷病毒-1整合酶抑制剂的最新研究情况进行综述。方法根据国内外文献报道,对已上市的3种人类免疫缺陷病毒-1整合酶抑制剂药物和新作用机制的整合酶抑制剂的研究情况进行归纳总结。结果与结论整合酶是人类免疫缺陷病毒-1病毒复制周期必需的基本酶之一,是新型抗艾滋病药物的作用靶点。随着人类免疫缺陷病毒耐药现象变得严重,整合酶抑制剂作为新作用机制的艾滋病治疗药物为临床提供了新的选择,新靶点和多靶点整合酶抑制剂的研发也使得未来人类免疫缺陷病毒治疗有更好的前景。
OBJECTIVE: To review recent studies on human immunodeficiency virus-1 integrase inhibitors. Methods According to the reports in the literature both at home and abroad, the researches on the integrase inhibitors of three kinds of human immunodeficiency virus-1 integrase inhibitor drugs and new mechanism of action on the market were summarized. Results and Conclusion Integrase is one of the essential enzymes required for replication of human immunodeficiency virus-1 virus and is a new target of anti-AIDS drugs. As human immunodeficiency virus resistance becomes more serious, integrase inhibitors as a new mechanism of action for the AIDS treatment of drugs provides a new clinical option, the development of new targets and multi-target integrase inhibitors also makes the future of human Immunodeficiency virus treatment has better prospects.