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为了评价一氧化氮（NO）在内毒素休克中的作用，应用脂多糖建立兔内毒素休克模型，然后分别应用N-硝基主旋精氨酸（L-NNA）和生理盐水静注治疗，分别测量治疗前后血压、血浆NO、环磷酸鸟苷（cGMP）和心钠素（ANF）。结果发现，内毒素休克时，血压下降，血浆NO、cGMP浓度升高，静注L-NNA（20mg／kg）治疗后休克大白兔血压升高，血浆NO、CGMP浓度下降。说明内毒素休克时机体内NO和cGMP产生增加，并与低血压有关，其机理是NO通过激活可溶性鸟苷酸环化酶，使cGMP增高所致，并提示L-NNA具有治疗内毒素休克的价值。
In order to evaluate the role of nitric oxide (NO) in endotoxic shock, lipopolysaccharide (LPS) was used to establish rabbit endotoxic shock model and then treated with L-NNA and saline respectively. Blood pressure, plasma NO, cGMP and ANF were measured before and after treatment respectively. The results showed that during endotoxic shock, blood pressure decreased and plasma NO and cGMP levels increased. After intravenous injection of L-NNA (20 mg / kg), the blood pressure of shocked rabbits increased and the concentrations of plasma NO and CGMP decreased. This suggests that NO and cGMP production is increased in endotoxin shock and is associated with hypotension. The mechanism is that nitric oxide increases the cGMP by activating soluble guanylate cyclase and suggests the value of L-NNA in the treatment of endotoxic shock .