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目的研究在烧伤及药理学实验中计算C57BL/6小鼠全身体表面积(BSA)时Meeh常数(k)的取值。方法测量20只C57BL/6小鼠的体重和BSA,并计算出小鼠的实际k值,比较其与5个正常小鼠常用k值(6.0、9.1、9.5、10.0和11.4)间的差异。结果小鼠BSA计算所得的k值为9.715±0.142,与正常小鼠常用k值比较差异均有统计学意义(P<0.01)。结论应用Meeh公式计算C57BL/6小鼠的BSA时,k值宜选用9.715。
Objective To investigate the value of Meeh constant (k) in calculating the total body surface area (BSA) of C57BL / 6 mice in burn and pharmacological experiments. Methods The body weight and BSA of 20 C57BL / 6 mice were measured and the actual k value of mice was calculated and compared with the common k value (6.0, 9.1, 9.5, 10.0 and 11.4) of 5 normal mice. Results The calculated k value of mouse BSA was 9.715 ± 0.142, which was significantly different from that of normal mice (P <0.01). Conclusion Meeh formula to calculate BSA C57BL / 6 mice, k value should be used 9.715.