采用兔眼前房穿刺后注入含枸橼酸钠的自体血浆0.2ml 的方法对14只兔(14只眼)建立了一定量、可重复的前房纤维蛋白渗出模型。24小时后将这些模型随机等分为两组,一组前房内注入 t-PA(4μg),另一组用等量生理盐水作对照。t-PA 治疗组纤维蛋白凝块平均在5小时内溶解,而对照组需7日方彻底清除。经裂隙灯检查、眼压测量、角膜内皮显微镜及光镜观察未见毒性作用。 Rabbit anterior chamber puncture after injection of autologous plasma containing sodium citrate 0.2ml of 14 rabbits (14 eyes) to establish a certain amount of reproducible fibrinolytic anterior chamber model. Twenty-four hours later, the models were randomly divided into two groups. One group received t-PA (4 μg) in the anterior chamber and the other group received normal saline. The fibrin clot in the t-PA group was dissolved within 5 hours on average, while the control group needed to be completely eliminated on the 7th day. Slit lamp examination, intraocular pressure measurement, corneal endothelial microscope and light microscopy showed no toxic effects.