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关于抗惊厥药和精神药物对男性生育能力的影响越来越受到关注。这些药物使用广泛,服用时间长。据报道,它们可引起精子活力下降、性功能减退。本文比较氯丙嗪、安定、苯妥英和苯巴比妥对人精子活力的影响以及咖啡因拮抗氯两嗪抑制精子活力的作用。试验用的人体精液中的精子数均高于15×10~6/ml,向前运动的精子数大于20%。试药溶于pH7.3的磷酸盐缓冲液中,与一定量精液混合后于37°孵育2小时
The impact of anticonvulsants and psychotropic substances on male fertility is receiving increasing attention. These drugs are widely used and take a long time. It is reported that they can cause decreased sperm motility, sexual dysfunction. This article compares the effect of chlorpromazine, diazepam, phenytoin and phenobarbital on human sperm motility and the effect of caffeine on the inhibition of chlorzoxazine on sperm motility. The number of spermatozoa in the test human semen was higher than 15 × 10 ~ 6 / ml, the number of sperm moving forward more than 20%. The reagent is dissolved in phosphate buffered saline (pH 7.3) and incubated with a given amount of semen for 2 hours at 37 °