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目的：探讨头孢呋辛（ｃｅｆｕｒｏｘｉｍｅ）、头孢呋辛酯（ｃｅｆｕｒｏｘｉｍｅａｘｅｔｉｌ）序贯治疗下呼吸道细菌感染的临床疗效、抗菌效果和不良反应。方法：男性２６例，女性１４例，年龄４３±ｓ８ａ（２６～７６ａ），痰细菌培养阳性细菌３２株。用头孢呋辛２．２５ｇ／ｄ，分２～３次静脉滴注，５～７ｄ后改口服头孢呋辛酯２５０ｍｇ，ｐｏ，ｂｉｄ，５～７ｄ。结果：痊愈２５例（６２％），显效１３例，总有效率达９５％，细菌清除率９４％（３０／３２株），无明显不良反应。结论：先静脉滴注头孢呋辛，继以头孢呋辛酯口服的序贯疗法治疗下呼吸道感染疗效良好，使用安全，可降低病人费用。
Objective: To investigate the clinical efficacy, antibacterial effects and adverse reactions of cefuroxime and cefuroxime axetil in sequential treatment of lower respiratory tract bacterial infections. Methods: There were 26 males and 14 females, aged 43 ± s8a (26 ~ 76a) and 32 sputum bacterial culture positive bacteria. With cefuroxime 2.25g / d, 2 to 3 times intravenously, 5 ~ 7d after oral cefuroxime axetil 250mg, po, bid, 5 ~ 7d. Results: 25 cases (62%) were cured, 13 cases were markedly effective, the total effective rate was 95%, and the bacterial clearance rate was 94% (30/32 strains) without obvious adverse reactions. Conclusion: The first intravenous injection of cefuroxime, followed by sequential oral cefuroxime axetil treatment of lower respiratory tract infection with good effect, safe to use, can reduce the cost of the patient.