1996年10月14～16日世界卫生组织在法国召开了关于全球急性呼吸道感染（ARI）及控制会议,会议指出,ARI是全球儿童的主要病因。呼吸道合胞病毒（RSV）和副流感病毒（PIV）疫苗常可预防最初感染;b型流感杆菌（Hib）和肺炎球菌菌苗可预防主要的细菌性死亡。在需要获得早期保护的发展中国家,母体接种尤为合适。由于那里就医较为困难,故联合疫苗的开发特别有益。在那些地区,新疫苗采用之前需经费用-效益论证。 October 14-16, 1996 WHO convened a conference on global acute respiratory infections (ARI) and control conferences in France. The meeting noted that ARI is the leading cause of childhood and childbirth in the world. Respiratory syncytial virus (RSV) and parainfluenza virus (PIV) vaccines often prevent the initial infection; b-type bacilli (Hib) and pneumococcal vaccine prevent major bacterial deaths. In developing countries that need early protection, maternal vaccination is particularly appropriate. The development of a combination vaccine is particularly beneficial as it is more difficult to see a doctor there. In those areas, a cost-benefit demonstration is needed before the new vaccine is introduced.