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变异性亚败血症(Subsepsis Allergica:Wissler 氏病)是一种少见的变态反应性综合症,原因不明,多发生于儿童,成人甚少罹患,从国内已发表的文献资料汇集17例中女性占65%,男性占35%发病年龄15～55岁。本病变态反应性现象甚为明显,临床上以间歇性弛张热,与变性皮疹及关节症状和血象增高,中性粒细胞增多等症状为特征。本病与类风湿性关节炎关系密切,血培养始终未证实有细菌,故有“亚败血症”的命名,抗菌素治疗完全无效,而肾上腺皮质激素是目前有效的药物,多数可以痊愈少数病例可转为慢性多发性关节炎,死亡率约4%。
Subsepsis Allergic (Subsepsis Allergica: Wissler’s disease) is an uncommon allergic syndrome with unknown causes, mostly in children, and very few adults. Of the 17 published cases, 65 %, Males accounted for 35% of the age of onset 15 to 55 years old. The disease is very obvious allergic reactions, clinically intermittent relaxation fever, and degeneration rash and joint symptoms and blood increased, neutrophils and other symptoms characterized. The disease is closely related to rheumatoid arthritis, blood culture has not been confirmed by bacteria, so the “sub-sepsis,” the name of the antibiotics completely null and void, while the adrenal cortex hormones are currently effective drugs, most can be cured a small number of cases can be transferred For chronic multiple arthritis, the mortality rate is about 4%.