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目的:了解不同剂量促红素(EPO)对维持性血透伴高血压者的动脉血压的影响。方法:25例维持性血透伴高血压患者分为2组,A组13例高剂量EP0组(9000u/w),B组12例低剂量EPO组(6000u/w),分别测定0周和4周的血红蛋白(Hb),红细胞压积(Hct),收缩压(SBP),舒张压(DBP),平均动脉压(MAP),并根据4周时的Hct升幅进一步将全部观察对象分成C组(△Hct<4%)和D组(△Hct≥4%),观察该分组时的血压情况。结果:(1)4周时,与B组相比,A组平均动脉压值高,血压升幅明显。(2)4周时,与C组相比,D组平均动脉血压值高,血压升幅明显。结论:对维持性血透伴高血压患者而言,高剂量EPO对升高血压的影响较低剂量明显,同时控制Hct升幅过快(<4%/月)可在一定程度上减轻EPO对血压升幅的影响。
Objective: To understand the effects of different doses of erythropoietin (EPO) on arterial blood pressure in maintenance hemodialysis patients with hypertension. Methods: Twenty-five patients with maintenance hemodialysis and hypertension were divided into two groups: 13 high-dose EPO group (9000u / w) in group A and 12 low-dose EPO group (6000u / w) Hb, Hct, DBP and MAP of 4 weeks, and all the subjects were further divided into group C according to the Hct increase at 4 weeks (△ Hct <4%) and group D (△ Hct≥4%). The blood pressure in this group was observed. Results: (1) At 4 weeks, compared with group B, group A had higher mean arterial pressure and increased blood pressure obviously. (2) Compared with group C, group D had higher mean arterial blood pressure and obvious increase of blood pressure at 4 weeks. CONCLUSIONS: The effect of high-dose EPO on lowering blood pressure is significantly lower for patients with maintenance hemodialysis and hypertension, while controlling Hct increase too fast (<4% / month) may reduce the effects of EPO on blood pressure The impact of the increase.