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作者用酮康唑(Ketoconazole)治疗了48例甲癣患者,其中2/3以上病例为女性,年龄14～78岁,平均43岁。1/3病例病程小于1年,2/3病例病程长达数年,绝大部分患者既往用过多种抗霉菌药物。治疗前均取甲板碎片作直接镜检、培养以及组织学检查,停药后至少观察18个月。48例中有37例为皮肤丝状菌,10例为酵母菌,1例为短帚霉菌。皮肤丝状菌中8例自手部、26例自足部分离到红色毛癣菌,3例自足部分离到趾间毛癣菌;10例酵母菌中6例为白色念珠菌,4例为其他念珠菌。所有患者(不分年龄大小)均于进食主餐时顿服
The authors treated 48 patients with onychomycosis with ketoconazole, two thirds of whom were female, aged 14-78 years (mean, 43 years). 1/3 of the course of disease less than 1 year, 2/3 case duration up to several years, the vast majority of patients in the past used a variety of anti-fungal drugs. Before treatment, take the deck fragments for direct microscopic examination, culture and histological examination, observed at least 18 months after withdrawal. Thirty-seven of the 48 cases were dermal filamentous bacteria, 10 were yeast, and 1 was Brucella. Trichophyton rubrum was isolated from 8 cases of filamentous fungus in the hands and from Trichophyton rubrum in 26 cases from the autologous portion of the skin, Candida All patients (regardless of age) were served daily with the main meal