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目的观察纳洛酮治疗慢性阻塞性肺疾病(COPD)并Ⅱ型呼吸衰竭患者的效果。方法选择72例明确诊断为COPD并Ⅱ型呼吸衰竭患者,随机分为治疗组和对照组。对照组采用常规治疗,治疗组在常规治疗的基础上加用纳洛酮,比较两组临床疗效和治疗前后血气变化情况。结果治疗组总有效率88.9%明显优于对照组的(61.1%),差异具有显著(P<0.01);治疗后氧分压(PO2)和二氧化碳分压(PCO2)改善情况与对照组具有显著差异(P<0.01)。结论纳洛酮治疗COPD并Ⅱ型呼吸衰竭是实用、安全、有效的,值得普遍推广。
Objective To observe the effect of naloxone on patients with chronic obstructive pulmonary disease (COPD) and type Ⅱ respiratory failure. Methods 72 patients with definite diagnosis of COPD and type Ⅱ respiratory failure were randomly divided into treatment group and control group. The control group was treated with conventional therapy. The treatment group was given naloxone on the basis of routine treatment. The clinical efficacy and blood gas changes before and after treatment were compared between the two groups. Results The total effective rate of treatment group was 88.9%, which was significantly higher than that of control group (61.1%), the difference was significant (P <0.01). After treatment, the improvement of PO2 and PCO2 was significant compared with that of control group Difference (P <0.01). Conclusion Naloxone is a practical, safe and effective method for the treatment of COPD and type Ⅱ respiratory failure, which is worthy of universal promotion.