胃液酶、单糖测定诊断胃癌的临床研究

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为了解胃液内β—萄葡糖醛酸酶(β—G)、亮氨酸氨基肽酶(LAP)、乳酸脱氢酶(LDH)、游离唾液酸(FSA)、岩藻糖(FUC)以及总唾液酸(TSA)改变对胃癌的诊断价值,作者对132例研究对象(对照组41例,轻度萎缩性胃炎36例,重度萎缩性胃炎20例和胃癌35例)作了上述项目测定。结果显示β—G、LAP和LDH单项测定胃癌阳性率分别为84.7%、80%和75%,联用三酶立方根之和(>23为阳性)作为判别标准,阳性率增至93.9%。FSA胃癌诊断阳性率(94%)略高于FUC(83%)和TSA(80%)。此外还发现重度萎缩性胃炎(伴肠化或不典型增生)者上述指标与胃癌有较大的重迭,提示这些病变具有胃癌的若干特性,这类“胃癌高危人群”必须重点随访复查。 慢性萎缩性胃炎(CAG)等癌前状态与胃癌发生的关系十分密切,但是究竟病变发展到何种程度或经过多少时间发生癌变至今知之甚少,人们试图寻找特异性强、敏感性高的胃癌标记物以检测和随访这些癌前期病变患者。 消化道肿癌患者病变粘膜内、胃肠分泌液以及血清中某些酶类异常增高。Rogers等应用胃液β—葡萄糖醛酸酶(β—G)/乳酸脱氢酶(LDH)测定诊断胃癌,临床符合率高达97.6%,引起广泛关注;黄介飞等亦证实胃粘膜肠腺化生上皮中亮氨酸氨基肽酶(LAP)活性增高,并与肠化程度成正比。 糖蛋白是细胞膜的重要组成成分,组织? To digest β-glucuronidase (β-G), leucine aminopeptidase (LAP), lactate dehydrogenase (LDH), free sialic acid (FSA), fucose (FUC) and in gastric juice The value of total sialic acid (TSA) changes in the diagnosis of gastric cancer, the author of 132 subjects (control group 41 cases, mild atrophic gastritis in 36 cases, severe atrophic gastritis in 20 cases and 35 cases of gastric cancer) made the above items. The results showed that the positive rates of β-G, LAP, and LDH were 84.7%, 80%, and 75%, respectively. The sum of the three enzyme cube roots (>23 was positive) was used as the criterion, and the positive rate was increased to 93.9%. The positive rate of FSA gastric cancer diagnosis (94%) was slightly higher than that of FUC (83%) and TSA (80%). In addition, it is also found that severe atrophic gastritis (with intestinal metaplasia or atypical hyperplasia) above indicators and gastric cancer have a greater overlap, suggesting that these lesions have a number of characteristics of gastric cancer, such “high risk population of gastric cancer” must focus on follow-up review. Precancerous conditions such as chronic atrophic gastritis (CAG) are closely related to the occurrence of gastric cancer. However, little is known about the extent to which lesions develop or how much time has passed since the onset of canceration. People have tried to find gastric cancers with strong specificity and high sensitivity. Markers to detect and follow-up these patients with precancerous lesions. Gastrointestinal squamous cell carcinoma patients in the mucosa, gastro-intestinal secretions and serum enzymes increased abnormally. Rogers et al used gastric fluid β-glucuronidase (β-G)/lactate dehydrogenase (LDH) for the diagnosis of gastric cancer. The clinical coincidence rate was as high as 97.6%, causing widespread concern; Huang Jiefei et al. also confirmed gastric mucosal glandular metaplasia in the epithelium. Leucine aminopeptidase (LAP) activity is increased and is proportional to the degree of intestinal metaplasia. Glycoprotein is an important component of the cell membrane, tissue?
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