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嗜酸性细胞(以下简称E)有二种特殊作用与嗜中性细胞(以下简称N)及其他白细胞不同:1.能使肥大细胞释放的介质灭活,因此可调节或阻抑肥大细胞的、与IgE介导脱粒有关的反应。2.破坏某些蠕虫蚴(特别是曼森氏血吸虫)。本文复习与E这些功能有关的生理、生化特性,并讨论此二种作用间的关系。若干年来已知道E选择性地对肥大细胞脱粒释放的趋化因子起反应。最早一组被明确地鉴定的趋化介质为四肽Ala-Gly-Ser-Glu及Val-Gly-Ser-Glu。最近已报告许多介质或多或少对E有选择性作用,包括组胺、醋酸咪
Eosinophils (hereinafter referred to as E) have two special effects and neutrophils (hereinafter referred to as N) and other leukocytes are different: 1. Mast cells can release media inactivation, it can regulate or suppress mast cells, IgE-mediated degranulation-related reactions. 2. Destruction of certain worm larvae (especially Manson’s schistosomes). This article reviews the physiological and biochemical characteristics associated with these E functions and discusses the relationship between these two effects. It has been known for some years that E selectively responds to chemokines released by threshing of mast cells. The first group of specifically identified chemotactic mediators are the tetrapeptides Ala-Gly-Ser-Glu and Val-Gly-Ser-Glu. A number of media have recently been reported to have a more or less selective effect on E, including histamine,