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通过拉曼光谱和红外光谱法分析对乙酰氨基酚包合物,探讨拉曼光谱作为一种新的验证包合物形成方法的可行性。采用饱和水溶液法制备对乙酰氨基酚包合物,共焦拉曼光谱仪和傅里叶转换红外光谱仪分别测定并获得-βCD、对乙酰氨基酚、摩尔比1∶1的-βCD与对乙酰氨基酚物理混合物及其包合物四种物质粉末的拉曼图谱和红外图谱并将其进行对照分析。拉曼图谱证明了对乙酰氨基酚以氢键作用嵌入β-环糊精的疏水空腔形成包合物,从而增加了它的稳定性和溶解度,与红外光谱结果一致。拉曼光谱法具有快速、准确、简便、无损测量等显著优势,可作为验证药物包合物的形成重要手段。
The analysis of acetaminophen inclusion by Raman spectroscopy and infrared spectroscopy to explore the feasibility of Raman spectroscopy as a new method to verify the formation of inclusion complex. Acetaminophen inclusion complex, confocal Raman spectroscopy and Fourier transform infrared spectroscopy were respectively used to prepare acetaminophen, acetaminophen, β-CD with a molar ratio of 1: 1 and acetaminophen Raman spectra and infrared spectra of the four physical powders and their inclusion complexes were compared and analyzed. Raman spectroscopy demonstrated that acetaminophen was embedded in the hydrophobic cavity of β-cyclodextrin to form an inclusion complex by hydrogen bonding, thereby increasing its stability and solubility, consistent with the results of infrared spectroscopy. Raman spectroscopy has the obvious advantages of rapid, accurate, simple and nondestructive measurement, which can be used as an important method to verify the formation of drug inclusion.