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目的为了探讨超大剂量化疗（ＨＤＣＴ）合并自体外周血造血干细胞移植（ＡＰＢＳＣＴ）治疗恶性肿瘤的临床意义。方法经病理证实的４例晚期恶性肿瘤接受了该治疗，采用小剂量Ｇ－ＣＳＦ加或不加化疗动员外周血造血干细胞（ＰＢＳＣ），均莸得足够的干细胞数量。３例患者采用ＣＴＸ５．６ｇ／ｍ２＋ＶＰ－１６１４００ｍｇ／ｍ２＋ＣＢＰ１０００ｍｇ／ｍ２，１例患者采用ＣＴＸ４．０ｇ／ｍ２＋ＥＰＩ１３０ｍｇ／ｍ２超大剂量化疗方案。结果化疗后完全缓解１例，部分缓解３例。ＡＰＢＳＣＴ后造血功能恢复非常迅速。结论采用化疗和／或小剂量Ｇ－ＣＳＦ动员ＰＢＳＣ是安全的和可行的，在ＡＰＢＳＣＴ支持下应用超大剂量化疗治疗对化疗敏感的恶性实体瘤是值得探索的方法。
Objective To investigate the clinical significance of high-dose chemotherapy (HDCT) combined with autologous peripheral blood stem cell transplantation (APBSCT) for the treatment of malignant tumors. Methods Four cases of advanced malignant tumors confirmed by pathology were treated with this method. Peripheral blood stem cells (PBSC) were mobilized with low doses of G-CSF with or without chemotherapy, and a sufficient number of stem cells were obtained. Three patients were treated with CTX5.6g/m2+VP-161400mg/m2+CBP1000mg/m2, and one patient was treated with CTX4.0g/m2+EPI130mg/m2 superdose chemotherapy. Results One case was completely relieved after chemotherapy and 3 cases were partially relieved. Hematopoietic function recovered very rapidly after APBSCT. Conclusion It is safe and feasible to mobilize PBSC with chemotherapy and/or low-dose G-CSF. It is worth investigating that a large dose of chemotherapy with APBSCT can be used to treat malignant solid tumors sensitive to chemotherapy.