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目的:观察蒙药光明盐四味汤散对非酒精性脂肪性肝病(NAFLD)模型小鼠血脂及肝功能的影响。方法:将小鼠造模后随机分空白组、模型组、硫普罗宁组和光明盐四味汤散组。模型组给予水和高脂饲料,硫普罗宁组给予硫普罗宁56mg/kg,光明盐四味汤组给予0.45g/kg光明盐四味汤散。灌胃4周后,眼眶采血,检测甘油三酯(TG)、胆固醇(TC)、谷丙转氨酶(ALT)、谷草转氨酶(AST)。结果:与模型组比较,光明盐四味汤散组血清TG、TC水平明显降低(P<0.05);两组血清ALT、AST比较差异无统计学意义。结论:光明盐四味汤散有明显降低NAFLD模型小鼠血清中的血脂作用,对肝脏保护功能虽无统计学意义,但也有一定的改善作用。
Objective: To observe the effect of Mongolian medicine Guangmingyan Siwei Tangsan on blood lipids and liver function in mice with nonalcoholic fatty liver disease (NAFLD). Methods: The mice were randomly divided into blank group, model group, tiopronin group and Guangmingyan Siwei Tangsan group. The model group was given water and high-fat diet, tiopronin group given tiopronin 56mg / kg, Guangming salt four-flavored soup group was given 0.45g / kg Guangming Siwei Tang San. After 4 weeks of gavage, orbital blood was collected for the detection of triglyceride (TG), cholesterol (TC), alanine aminotransferase (ALT) and aspartate aminotransferase (AST). Results: Compared with the model group, serum TG and TC levels in Guangming SSP group were significantly decreased (P <0.05). There was no significant difference in serum ALT and AST between the two groups. Conclusion: Guangmingyan Siwei Tang San can obviously reduce the serum lipids in NAFLD mice, and has no significant effect on the liver protection, but it also has certain improvement effect.