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应用透射电镜对17例恶性黑素瘤(MM)进行观察,并以30例色素痣作对照,重点探讨异常黑素小体在MM诊断中的价值。14例MM包括2例无色素性MM中找到异常黑素小体,2例含色素及1例无色素性MM中未找到异常黑素小体;4例先天性痣中发现异常黑素小体。结果提示:异常黑素小体对MM的诊断有重要参考价值,但以往对其意义估价过高,作者认为MM的透射电镜诊断需结合其它超微结构改变综合判断。
Transmission electron microscopy was used to observe 17 cases of malignant melanoma (MM), and 30 cases of pigmented nevus were used as controls to investigate the value of abnormal melanosomes in the diagnosis of MM. The abnormal melanosome was found in 14 cases of MM including 2 cases of non-pigmented MM, abnormal melanoid bodies were not found in 2 cases of pigment-containing and 1 case of non-pigmented MM; abnormal melanoid bodies were found in 4 cases of congenital hernia. . The results suggest that abnormal melanoid bodies have important reference value for the diagnosis of MM, but in the past, their significance was overestimated. The authors believe that TEM diagnosis should be combined with other ultrastructural changes to make a comprehensive judgment.