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目的观察瑞替普酶联合还原型谷胱甘肽治疗急性ST段抬高型心肌梗死对患者相关指标及左心室功能的影响。方法将202例急性ST段抬高型心肌梗死患者随机分为观察组和对照组,各101例。观察组给予瑞替普酶联合还原型谷胱甘肽和常规治疗,对照组仅给予瑞替普酶和常规治疗,分别于治疗前后检测2组患者血清相关指标及左心室功能变化。结果观察组治疗后血清肌酸激酶同工酶(CK-MB)、心肌肌钙蛋白T(c Tn T)、心肌肌钙蛋白I(c Tn I)水平均低于对照组,而左心室射血分数(LVEF)水平高于对照组,左心室收缩末期容积(LVEDV)和左心室舒张末期容积(LVESV)低于对照组,差异均有统计学意义(P<0.05)。结论瑞替普酶联合还原型谷胱甘肽治疗急性ST段抬高型心肌梗死可显著缓解患者血清CK-MB、c Tn T和c Tn I等指标,改善其左心室功能。
Objective To observe the effects of reteplase combined with reduced glutathione (GSH-GS) on the related indexes and left ventricular function in patients with acute ST-segment elevation myocardial infarction. Methods A total of 202 acute ST-segment elevation myocardial infarction patients were randomly divided into observation group and control group, each with 101 cases. The observation group received reteplase combined with reduced glutathione and conventional treatment, the control group was given only reteplase and routine treatment, respectively, before and after treatment to detect two groups of patients serum-related indicators and changes in left ventricular function. Results After treatment, the levels of serum CK-MB, cTn T and cTn I in the observation group were lower than those in the control group, while the left ventricular ejection The level of LVEF was higher than that of the control group. The LVEDV and LVESV were lower than those of the control group (P <0.05). Conclusion The combination therapy of reteplase and reduced glutathione in acute ST-elevation myocardial infarction can significantly relieve the serum CK-MB, cTn T and cTn I and improve their left ventricular function.