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目的:观察并分析血液灌流联合血液透析对重症急性胰腺炎患者的治疗效果。方法:选取本院2013年4月-2015年8月收治的重症急性胰腺炎患者50例作为研究对象,依照患者治疗意愿和随机数表法将患者均分为甲组和乙组各25例。两组患者均进行常规治疗,甲组患者在常规治疗基础上采取单纯血液灌流治疗,乙组在常规治疗基础上采取血液灌流联合血液透析治疗,观察两组患者血液生化检查结果变化、临床指标变化、并发症发生率、致死率及总住院时间等治疗情况。结果:治疗结束后,两组患者生化检查结果与治疗前相比均明显好转,且乙组患者检查结果改善情况明显优于甲组患者,差异具有统计学意义(P<0.05);两组患者治疗后基本生命体征均处于平稳状态,与治疗前相比改善效果明显,差异有统计学意义(P<0.05);乙组患者临床治疗效果明显优于甲组,差异具有统计学意义(P<0.05)。结论:针对重症急性胰腺炎患者采取血液灌流联合血液透析治疗方式,能够稳定、有效地清除患者血液中毒素及炎性介质,不仅可以减少患者并发症发生率,降低重症急性胰腺炎致死率,同时还可以尽快帮助患者改善临床症状,并缩短患者住院时间,治疗价值显著。
Objective: To observe and analyze the therapeutic effect of hemoperfusion and hemodialysis on patients with severe acute pancreatitis. Methods: Fifty patients with severe acute pancreatitis who were treated in our hospital from April 2013 to August 2015 were selected as the research object. All patients were divided into two groups according to their willingness of treatment and random number table. Patients in both groups were treated routinely. Patients in group A were treated with hemoperfusion only on the basis of routine treatment. Group B was treated with hemoperfusion combined with hemodialysis on the basis of routine treatment. Changes in blood biochemical test results and clinical indicators were observed , Complication rate, fatality rate and total length of stay. Results: After treatment, biochemical test results of both groups were significantly improved compared with those before treatment, and the improvement of test results in group B was obviously better than that in group A (P <0.05). The two groups of patients After treatment, the basic vital signs were in a steady state, with significant improvement compared with before treatment, the difference was statistically significant (P <0.05); Group B patients with clinical treatment was significantly better than Group A, the difference was statistically significant (P < 0.05). Conclusion: The hemoperfusion combined with hemodialysis treatment for patients with severe acute pancreatitis can remove the toxins and inflammatory mediators stably and effectively, not only can reduce the incidence of complications and reduce the mortality of severe acute pancreatitis, at the same time As soon as possible to help patients improve clinical symptoms, and shorten the hospital stay, the treatment of significant value.