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目的探讨抑癌基因(PTEN)、细胞增殖核抗原(PCNA)和原癌基因(CerbB2)在正常子宫内膜(NE)、非典型增生内膜(AHE)及癌性组织(CE)中的表达,并分析其临床意义。方法于2003年9月至2005年3月采用免疫组织化学SP法,检测天津医科大学总医院35例NE,38例AHE和65例CE中PTEN、PCNA和CerbB2的蛋白表达。结果在NE、AHE和CE中PTEN表达缺失为0、28.9%和55.4%;PCNA表达阳性率为8.6%、47.4%和78.5%;CerbB2阳性率为14.3%、23.7%和40.0%。PTEN的缺失与临床分期和病理分级相关;PCNA阳性表达与病理分级和淋巴转移相关;CerbB2阳性表达与临床分期、肌层浸润和淋巴转移相关。结论PTEN、PCNA和CerbB2与子宫内膜癌的发生、发展、治疗及预后密切相关。
Objective To investigate the expression of tumor suppressor gene (PTEN), proliferating cell nuclear antigen (PCNA) and oncogene (CerbB2) in normal endometrium (NE), atypical endoderm (AHE) and cancerous tissues , And analyze its clinical significance. Methods Immunohistochemical SP method was used to detect the protein expression of PTEN, PCNA and CerbB2 in 35 cases of NE, 38 cases of AHE and 65 cases of CE in Tianjin Medical University General Hospital from September 2003 to March 2005. Results The deletion of PTEN in NE, AHE and CE was 0, 28.9% and 55.4% respectively. The positive rates of PCNA expression were 8.6%, 47.4% and 78.5%. The positive rates of CerbB2 were 14.3%, 23.7% and 40.0% respectively. The loss of PTEN was correlated with clinical stage and pathological grade. The positive expression of PCNA correlated with pathological grade and lymphatic metastasis. The positive expression of CerbB2 was correlated with clinical stage, myometrial invasion and lymphatic metastasis. Conclusions PTEN, PCNA and CerbB2 are closely related to the occurrence, development, treatment and prognosis of endometrial carcinoma.