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目的:探讨急性有机磷农药中毒(AOPP)患者血清心肌肌钙蛋白-T(CTnT)和肌酸激酶同功酶(CK-MB)的改变及临床价值。方法:采用ELISA法和免疫抑制法分别定100例AOPP患者和100例健康体检者血清CTnT和CK-MB水平。结果:AOPP组中毒后6h、24h、72h时的血清CTnT和CK-MB水平明显高于对照组,相比较有统计学差异(P<0.05);血清CTnT和CK-MB水平随着中毒程度加重而升高,CTnT、CK-MB与不同中毒程度分级呈正相关(r=0.569,0.498,P<0.01)。结论:联合监测AOPP患者血清CTnT和CK-MB有助于判断中毒程度,AOPP患者血清CTnT和CK-MB的升高对心肌受损具有重要的诊断价值。
Objective: To investigate the changes and clinical value of serum cardiac troponin T (CTnT) and creatine kinase isoenzyme (CK-MB) in patients with acute organophosphorus pesticide poisoning (AOPP). Methods: Serum levels of CTnT and CK-MB in 100 AOPP patients and 100 healthy controls were determined by ELISA and immunosuppression respectively. Results: Serum levels of CTnT and CK-MB at 6h, 24h and 72h after poisoning in AOPP group were significantly higher than those in control group (P <0.05). Serum levels of CTnT and CK-MB increased with the increase of poisoning However, CTnT and CK-MB were positively correlated with different degrees of poisoning (r = 0.569,0.498, P <0.01). Conclusion: The combined monitoring of serum CTnT and CK-MB in patients with AOPP can help determine the degree of poisoning. The elevated serum levels of CTnT and CK-MB in AOPP patients have important diagnostic value for myocardial damage.