论文部分内容阅读
大量研究资料证明,茶碱生效和中毒直接与血浓度有关。因而在血浓度监测下,使用茶碱类制剂,不仅大大增加了它作为急性支气管扩张剂的有效性和安全性,而且扩展了它的预防复发作用。一、监测血浓度的理论基础1.茶碱血浓度与临床反应的关系:①可逆性气道梗阻住院病人:当茶碱血浓度达到5～20μg/ml时,支气管扩张作用增加,哮喘减轻,并减少对其它止喘药的需要。40例病人长期口服茶碱,其中33人肺能功改善15%,4人主观感觉改善。②运动性哮喘:茶碱血浓度>10μg/ml对运动性哮喘产生抑制作用。>15μg/ml抑制作用更强,持续用药可预防运动性哮喘发
A large number of research data show that theophylline effect and poisoning directly related to blood concentration. Thus, the use of a theophylline preparation under blood concentration monitoring not only greatly increases its effectiveness and safety as an acute bronchodilator, but also expands its effectiveness in preventing relapse. First, the theoretical basis for monitoring blood concentration 1. Theophylline blood concentration and clinical response: ① reversible airway obstruction inpatients: when theophylline blood concentration reached 5 ~ 20μg / ml, increased bronchodilation, reduce asthma, And reduce the need for other asthma medications. 40 patients long-term oral theophylline, 33 of them improved 15% of lung function, 4 subjective feeling improved. ② exercise-induced asthma: theophylline blood concentration> 10μg / ml of exercise-induced asthma inhibition. > 15μg / ml stronger inhibitory effect, continuous medication can prevent exercise-induced asthma attacks