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目的探讨MERLIN与颞叶癫痫海马硬化间的相互关系。方法采用马桑内酯慢性致痫大鼠模型,通过免疫组化方法观察MERLIN在点燃组、未点燃组及对照组中颞叶皮层及海马CA1区的表达。结果在点燃组颞叶皮层及海马CA1区神经元MERLIN的表达较未点燃组及对照组的表达有增多(P<0.05),而未点燃组与对照组之间在神经元表达上差异无统计学意义(P>0.05)。各组在上述部位胶质细胞的表达均较少。结论MERLIN在马桑内酯点燃大鼠模型颞叶皮层及海马CA1区神经元中的过度表达可能参与了神经元凋亡、海马硬化的过程。
Objective To explore the relationship between MERLIN and temporal lobe hippocampal sclerosis. Methods The model of chronic epilepticus was established by immunohistochemistry to observe the expression of MERLIN in the temporal lobe cortex and hippocampal CA1 region in the ignited group, the non-ignited group and the control group. Results The expression of MERLIN in the temporal lobe cortex and hippocampal CA1 neurons in the ignited group was higher than that in the non-ignited group and the control group (P <0.05), but there was no statistical difference in neuron expression between the non-ignited group and the control group Significance (P> 0.05). Each group in the above parts of the expression of glial cells are less. Conclusions The overexpression of MERLIN in temporal lobe cortex and hippocampal CA1 neurons in the rat model of intraocular administration of mayanone may be involved in neuronal apoptosis and hippocampal sclerosis.