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目的:探讨血清可溶性转铁蛋白受体(sTfR)作为重型β地中海贫血(β地贫)患儿机体铁负荷指标的可行性。方法:对20例重型β地贫未接受过输血、20例重型β地贫接受规则输血及40例正常健康儿童的血红蛋白量(Hb)、铁蛋白(SF)以及sTfR进行检测,应用单变量回归分析分析20例重型β地贫未接受过输血患儿的sTfR与SF2者之间有无相关关系。结果:①重型β地贫未接受输血患儿的Hb值明显低于那些接受规则输血及正常对照儿童,而SF与sTfR水平则明显高于那些接受规则输血及正常对照儿童。②单变量回归分析显示sTfR与SF2者之间存在直线正相关,sTfR水平随着SF水平的增高而增高。结论:sTfR可作为一项监测重型β地贫患儿机体铁负荷的指标。
Objective: To investigate the feasibility of serum soluble transferrin receptor (sTfR) as an indicator of iron load in children with severe β-thalassemia (β-thalassemia). Methods: Twenty hemoglobin (Hb), ferritin (SF) and sTfR in 20 patients with severe thalassemia of β-thalassemia who were transfused without blood transfusion, 20 patients with severe thalassemia of β-thalassemia and 40 healthy children were tested by univariate regression Analysis of 20 cases of severe β-thalassemia non-transfusion-dependent children with sTfR and SF2 have no correlation between. Results: (1) Hb levels in children with severe β thalassemia who did not receive transfusion were significantly lower than those in children who received regular transfusion and control, while SF and sTfR levels were significantly higher in those who received regular transfusion and controls. (2) Univariate regression analysis showed that there was a linear positive correlation between sTfR and SF2, sTfR level increased with the increase of SF level. Conclusion: sTfR can be used as an indicator of body iron overload in children with severe β thalassemia.