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目的观察思他宁治疗非静脉曲张性上消化道大出血的疗效及安全性。方法随机将符合非静脉曲张性上消化道大出血的98例患者分为思他宁组和奥美拉唑组,对两组患者的平均输血量、治疗效果、不良反应和死亡率进行综合比较。结果思他宁组平均输血量(410.5±130.4)ml,显著低于奥美拉唑组(487.6±121.2ml)(P<0.05);思他宁组显效率92.3%,显著高于奥美拉唑组(82.6%)(P<0.05),而两组总有效率无显著性差异(P>0.05);思他宁组与奥美拉唑组不良反应发生率分别为3.8%和8.7%,无显著性差异(P>0.05),而思他宁组死亡率1.9%,显著低于奥美拉唑组的4.5%(P<0.05)。结论思他宁治疗非静脉曲张性上消化道大出血疗效可靠,止血快,无不良反应。
Objective To observe the efficacy and safety of Stilamin in treating non-variceal upper gastrointestinal hemorrhage. Methods A total of 98 patients with non-variceal upper gastrointestinal hemorrhage were randomly divided into statin and omeprazole groups. The mean blood transfusion volume, treatment effect, adverse reaction and mortality of the two groups were compared. Results The mean blood transfusion volume was (410.5 ± 130.4) ml in simvastatin group, which was significantly lower than that in omeprazole group (487.6 ± 121.2 ml) (P <0.05), and that in simvastatin group was 92.3% (P <0.05). There was no significant difference in the total effective rate between the two groups (P> 0.05). The incidence rates of adverse reactions in the astatine group and omeprazole group were 3.8% and 8.7% respectively, There was no significant difference (P> 0.05), while the statin group mortality was 1.9%, significantly lower than the 4.5% omeprazole group (P <0.05). Conclusion Stilamin treatment of non-variceal upper gastrointestinal bleeding reliable, fast bleeding, no adverse reactions.