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目的了解深圳地区人群乙肝疫苗接种后对抗-HBs的影响。方法采用单纯随机抽样的方法对1996～2003年来某院健康体检的资料完整的35000人进行HBsAg和抗-HBs调查。结果35000人中HBsAg平均阳性率为4.82%,抗-HBs平均阳性率为61.47%。抗-HBs阴性和抗-HBs阳性人群乙肝疫苗的平均接种率分别是99.92%和94.92%;乙肝疫苗接种后第1年和第3年检测抗-HBs阳性水平;全阴者平均抗-HBs阳性率分别为95.61%和37.46%;加强接种者平均抗-HBs阳性率分别为86.83%和57.62%。结论接种乙肝疫苗是预防乙型肝炎的最有效措施,乙肝疫苗接种3a后抗-HBs下降明显,需加强免疫。
Objective To understand the influence of anti-HBs after hepatitis B vaccination in Shenzhen population. Methods A simple random sampling method was used to investigate the HBsAg and anti-HBs in the 35000 healthy people whose health examination was completed in a hospital from 1996 to 2003. Results The average positive rate of HBsAg in 35000 people was 4.82%, and the average positive rate of anti-HBs was 61.47%. The average inoculation rates of hepatitis B vaccine in anti-HBs and anti-HBs positive population were 99.92% and 94.92% respectively. The positive anti-HBs were detected in the first year and the third year after hepatitis B vaccination. The average anti-HBs positive The rates of positive anti-HBs were 86.83% and 57.62%, respectively. Conclusion Hepatitis B vaccination is the most effective measure to prevent hepatitis B. Anti-HBs decreased obviously after vaccination with hepatitis B vaccine for 3 years.