自发性高血压大鼠(SHR)心肌肥厚的程度和血压水平并不平行,提示除血压以外,尚有其它因素参与SHR 的心肌肥厚,有可能心肌细胞本身是主要的因素。作者设想心肌细胞在应激情况下,局部性释放一种能加速蛋白合成因子。通过研究体外心肌细胞蛋白合成,发现 SHR 心肌细胞匀浆上清能促进心肌细胞蛋白合成,表现为:掺入到蛋白合成中氚标记亮氨酸量增加,一种特异性 tRNA 活性增加。从这种匀浆上清中用 Cardiac hypertrophy in spontaneously hypertensive rats (SHRs) is not paralleled by the level of blood pressure, suggesting that other factors other than blood pressure are involved in cardiac hypertrophy in SHR and that cardiomyocytes may themselves be the predominant factor. The authors hypothesized that cardiomyocytes release locally under stress conditions a protein that accelerates protein synthesis. By studying the protein synthesis of cardiomyocytes in vitro, we found that SHR cardiomyocytes homogenate supernatant can promote the protein synthesis of cardiomyocytes, which is as follows: the amount of tritiated leucine incorporation into the protein synthesis increases, and the activity of a specific tRNA increases. Used from this homogenate supernatant