本实验为探讨激素替代治疗中孕激素的加用方式问题 ,以去势后 SD雌性大鼠作为动物模型 ,以核分裂率与增殖细胞核抗原指数作为指标 ,模拟临床激素替代疗法中两种孕激素的加用方式——连续与周期 ,短期给药 6 d,观察大鼠子宫内膜的增殖与抑制情况。结果显示单纯雌激素给药 ,开始时子宫内膜明显增殖 ;而雌孕激素联合用药时则从用药开始内膜即被抑制 In this study, to explore the hormone replacement therapy in the use of progesterone plus the way to SD female rats after castration as an animal model to mitotic index and proliferating cell nuclear antigen index as an indicator of clinical hormone replacement therapy in the two progesterone Plus way - continuous and periodic, short-term administration of 6 d, observe the endometrial proliferation and inhibition. The results showed that the administration of estrogen alone, the beginning of the endometrial significantly proliferate; while the combination of estrogen and progesterone medication from the beginning of the administration is inhibited