AIM:To evaluate quality of life (QoL) after curative liver resection and identify variables associated with decreased QoL.METHODS: From October 2001 to July 2004, 323patients underwent liver resection. At 3-36 mo after discharge, 188 patients were disease free. QoL was assessed using the Short Form (SF)-12 Health Survey with mental and physical component scales (SF-12 MCS and PCS), supplemented with generic questions concing pain and liver-specific items.RESULTS: Sixty-eight percent (128/188) reted the questionnaire, which was completed in 75% (96/128) of cases. Median SF-12 PCS and MCS were 46.7 (interquartile range: 34.2-53.9) and 54.1 (42.8-58.2). Fifty percent were pain free with a median symptom score of 1.75 (1.38-2.13). PCS was higher after major hepatectomy hepatectomy[57% (55/96)] compared to minor resection ( P =0.0049), which represented an improved QoL. QoL was not affected by sex but by age compared to the general German population. MCS was higher after liver surgery for metastatic disease [55.9 (47.5-58.8)] compared to primary carcinoma [49.6 (36.5-55.1)] and benign disease [49.2 (37.7-56.3)] ( P = 0.0317). There was no correlation between length of postoperative period and QoL. Pain, deficiencies in everyday life and a high symptom score significantly decreased MCS and PCS.CONCLUSION: Most patients were only marginally affected even after major liver resection; however, minor complications were associated with decreased SF-12MCS and PCS and need careful attention.