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目的对照单纯经肝动脉化疗栓塞术（ＴＡＣＥ），研究暂时阻断肝静脉后行肝动脉化疗栓塞术（ＴＡＣＥＴＨＶＯ）治疗原发性肝癌的药代动力学变化。方法为了进行药代动力学研究，随机将病人分为两组，ＴＡＣＥ组和ＴＡＣＥＴＨＶＯ组。采用高效液相色谱仪测定肝静脉和外周静脉血中５氟尿嘧啶（５Ｆｕ）的血药浓度，进行药代动力学分析。结果肝静脉和外周静脉血中５Ｆｕ的曲线下面积比值，ＴＡＣＥＴＨＶＯ组明显大于ＴＡＣＥ组；肝静脉血中５Ｆｕ的峰浓度，ＴＡＣＥＴＨＶＯ组明显高于ＴＡＣＥ组。同组中肝静脉和外周静脉的５Ｆｕ浓度趋向一致时间，ＴＡＣＥＴＨＶＯ组３０分钟，ＴＡＣＥ组为６分钟。结论暂时阻断肝静脉后行肝动脉化疗栓塞术可明显提高肿瘤局部的药物浓度，延长作用时间，加倍提高了抗肿瘤的效果，该法在临床上有很好的应用价值
Objective To compare the pharmacokinetics of hepatocellular carcinoma with TACE-THVO after transient hepatic vein occlusion (TACE). Methods For pharmacokinetic studies, patients were randomly divided into two groups, the TACE group and the TACE-THVO group. The plasma concentrations of 5-fluorouracil (5-Fu) in hepatic vein and peripheral vein blood were measured by HPLC and pharmacokinetic analysis was performed. Results The area ratio of 5-FU in hepatic vein and peripheral venous blood was significantly higher in TACE-THVO group than in TACE group. The peak concentration of 5-Fu in hepatic venous blood was significantly higher in TACE-THVO group than in TACE group. The concentration of 5-Fu in the hepatic vein and peripheral vein in the same group tended to be the same time, 30 minutes in the TACE-THVO group and 6 minutes in the TACE group. Conclusion Transcatheter arterial chemoembolization after hepatic vein occlusion can significantly increase the local drug concentration, prolong the action time, and double the anti-tumor effect. This method has a good clinical application value.