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应用显微外科技术，在建立稳定可靠、重复性好、与人的脑栓塞病程相近的大鼠局灶性脑缺血模型的基础上，模拟出缺血性中风患者的脑内９９ｍＴｃ－ＨＭ－ＰＡＯ的分布状况。１１只大鼠大脑中动脉阻塞（ＭＣＡｏ）后病灶侧与健侧的放射性计数比值为０．７７±０．２４，与对照组的比值有显著性差异（Ｐ＜０．０５），与病理所见及神经症状改变的符合性好．印证了９９ｍＴｃ－ＨＭ－ＰＡＯ能很好地反映脑血流灌注状况，用于脑疾病的临床诊断有确切的意义。
The application of microsurgical techniques in establishing a stable and reliable, good repeatability, and similar to the course of human cerebral embolism in rat focal cerebral ischemia model, based on the simulation of ischemic stroke in patients with brain 99mTc-HM- PAO distribution. The radioactive count ratio of lesion side and contralateral side in 11 rats with middle cerebral artery occlusion (MCAo) was 0.77 ± 0.24, which was significantly different from the control group (P <0.05) See the change of neurological symptoms and good compliance. Confirmed 99mTc-HM-PAO can well reflect the status of cerebral perfusion for the clinical diagnosis of brain disease has a definite meaning.