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本文报导仙灵脾等补肾药对小鼠迟发性足垫反应的影响.小鼠灌服中药煎液(60%,0.5ml)连续8天,给药第4天腹腔注射SRBC致敏,第8天足垫皮下注射SRBC攻击,24小时后测量足垫肿胀数值.杂种鼠各用药组与对照组比较无明显差别,而C_(57)BL小鼠仙灵脾组的足垫肿胀数值明显高于对照组.攻击后12、24和40小时测3次足垫肿胀数值观察足垫反应动力学变化的结果表明,仙灵脾和肉苁蓉组在攻击后24小时的足垫反应相对强度高于对照组.足垫反应高峰一般在攻击后24小时,但鹿茸精组的足垫反应高峰后移.本文结果提示仙灵脾和肉苁蓉在体内可能有促进细胞免疫功能的作用,具体环节有待深入探讨.
This article reports the effect of the Chinese herb of the kidney, spleen, and other kidneys on the delayed footpad reaction in mice. The mice were given Chinese herbal decoction (60%, 0.5 ml) for 8 consecutive days, and the SRBC was injected intraperitoneally on the 4th day after administration. After 8 days of footpad injection of SRBC, the footpad swelling was measured 24 hours later. There was no significant difference between the crossbreed rats in each drug group and the control group, but the footpad swelling of the C_(57)BL mice in the Xianlingpi group was significantly higher. At the 12th, 24th, and 40th hour post-challenge, the footpad swelling was measured 3 times. The results of the change in the footpad dynamics showed that the relative intensity of the footpad reaction 24 hours after the attack was higher in the epimedium and the Cistanche group than in the control group. The peak of the footpad reaction was generally 24 hours after the challenge, but the peak of the footpad reaction of the pilose antler group moved backwards. The results of this paper suggest that the epilepsy and Cistanche may have the function of promoting cellular immune function in vivo, and the specific link needs further discussion.