胞壁酰二肽(MDP)是细菌细胞壁肽聚精的最小结构单位,在免疫应答中产生佐剂活性。MDP的多种类似物和衍生物已被人工合成,它们对肿瘤和感染的免疫学活性和免疫治疗作用已有报道。B30-MDP是一种亲脂性MDP的衍生物,它能增强豚鼠对卵清蛋白的迟发型超敏反应的诱导,诱导小鼠抗同种异体肿瘤的杀伤性T细胞的产生,X线照射的肿瘤细胞与B30-MDP混合物免疫豚鼠可诱发有效的抗肿瘤免疫应答。 Muramyl dipeptide (MDP) is the smallest structural unit of bacterial cell wall peptide polygalactin that produces adjuvant activity in an immune response. A number of analogs and derivatives of MDP have been synthesized and their immunological activity on tumors and infections has been reported. B30-MDP is a derivative of lipophilic MDP that enhances the induction of delayed type hypersensitivity to ovalbumin in guinea pigs and induces the production of killer T cells against allogeneic tumors in mice. X-ray irradiation Guinea pigs immunized with a mixture of tumor cells and B30-MDP elicited a potent anti-tumor immune response.