[Gao Y,et al.Cancer Res,2016]肾癌是泌尿系统常见的恶性肿瘤,发病率较高,约占全身恶性肿瘤的4.2%。50%以上的肾癌患者早期并无特异性症状,发现时多已进入中晚期,而且约1/3的患者已有转移。转移后肾癌患者预后尤其不佳,5年生存率仅有10%。为了明确肾癌侵袭转移的相关分子机制,我们对转移性肾透明细胞癌(clear cell renal caicinoma,ccRCC)患者样本进行了基 [Gao Y, et al. Cancer Res, 2016] Kidney cancer is a common malignancy of the urinary system, with a high incidence, accounting for 4.2% of all malignant tumors of the body. More than 50% of patients with renal cell carcinoma early no specific symptoms, found that more have entered the advanced stage, and about 1/3 of patients have been transferred. The prognosis of patients with metastatic renal cell carcinoma is particularly poor, 5-year survival rate was only 10%. In order to clarify the molecular mechanisms involved in the invasion and metastasis of renal carcinoma, we conducted a series of studies on the samples of patients with metastatic clear cell renal caicinoma (ccRCC)