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目的研究清幽和胃汤联合西医三联疗法治疗幽门螺杆菌(Hp)阳性消化性溃疡的疗效。方法选择门诊60例胃镜确诊Hp阳性消化性溃疡患者为研究对象,随机分成实验组30例(中药联合西医三联疗法)与对照组30例(西医三联疗法),比较两组患者的症状改善情况、Hp根除率、不良反应率。结果经治疗后,实验组证候积分为(3.35±1.20),对照组证候积分为(4.15±1.30),组间比较差异具统计学意义(t=2.578,P<0.05),实验组患者症状改善总有效率达93.3%,对照组为70.0%,组间比较差异有统计学意义(P<0.05);实验组患者Hp根除率为83.3%,而对照组为60.0%,组间比较差异有统计学意义(P<0.05);实验组患者不良反应率为3.3%,而对照组为10.0%,组间比较差异无统计学意义(P>0.05)。结论清幽和胃汤联合西医三联疗法治疗Hp阳性消化性溃疡疗效优越,且不增加不良反应事件,值得临床推广。
Objective To study the curative effect of Qingyou and Weitang combined with western medicine triple therapy on Helicobacter pylori (Hp) -positive peptic ulcer. Methods A total of 60 patients with Hp-positive peptic ulcer diagnosed by endoscopy were selected as study objects and randomly divided into experimental group (30 cases) and control group (30 cases) treated with western medicine and triple therapy. The improvement of symptoms was compared between the two groups. Hp eradication rate, adverse reaction rate. Results After treatment, the scores of syndromes in the experimental group were (3.35 ± 1.20) and those in the control group were (4.15 ± 1.30), the difference was statistically significant (t = 2.578, P <0.05) The total effective rate of symptom improvement was 93.3% and that of the control group was 70.0%, the difference between the two groups was statistically significant (P <0.05). The Hp eradication rate was 83.3% in the experimental group and 60.0% in the control group (P <0.05). Adverse reaction rate was 3.3% in the experimental group and 10.0% in the control group, with no significant difference between the two groups (P> 0.05). Conclusion Qingyou stomach soup combined with western medicine triple therapy Hp-positive peptic ulcer superior efficacy, and does not increase the adverse reaction events, is worth clinical promotion.