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目的 为了评述一群荷兰HIV—1感染的血友病病人其HIV病的进展以及为了研究临床因素和凝血因子的影响,作者进行了15年纵向的临床和实验室研究。方法 对1981年至1995年7月前52例感染HIV—1的血友病病人进行了以后的研究:AIDS进展与血友病类型、抗因子Ⅷ抗体、年龄、巨细胞病毒(CMV)感染以及所消耗的凝血因子种类及总量的相关性。结果 在有抗因子Ⅷ抗体(抑制剂)的一组病人和一组乙型血友病人比一组无抑制剂的甲型血友病病人其AIDS进展较快。结论 作者结
Objective To review the progress of HIV in a group of hemophiliacs infected with HIV-1 in the Netherlands and to investigate the clinical and clotting factors, the authors conducted 15 years of longitudinal clinical and laboratory studies. Methods Fifty-two HIV-1-infected hemophilia patients from 1981 to July 1995 were studied later: AIDS progression and hemophilia type, anti-factor Ⅷ antibody, age, cytomegalovirus (CMV) infection and The type and total consumption of coagulation factors. Results A group of patients with an anti-factor Ⅷ antibody (inhibitor) and a group of hemophilia B progressed more rapidly than a group of uninhibited hemophilia A patients. Conclusion author’s conclusion