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目的:观察清热解毒饮配合放疗治疗鼻咽癌的疗效及毒副反应。方法:2001年1月～2004年1月将78例中晚期鼻咽癌患者随机分为两组:联合治疗组(放疗+清热解毒饮)39例,对照组(单纯放疗)39例。两组采用常规分割照射,靶区包括鼻咽部原发灶、颅底及颈部转移灶。联合治疗组放疗第1天开始服用清热解毒饮,1剂/日,连用至放疗结束。结果:联合治疗组3、5年生存率分别为82.05%,64.10%,对照组为71.79%,48.72%,两组Ⅰ度以上放射性口咽反应发生率分别为:25.64%和53.84%;而消化道反应两组发生率分别为7.69%和23.07%。结论:清热解毒饮与放疗同步治疗鼻咽癌与单纯放疗两组间有显著性差异(P<0.05),提示清热解毒饮配合放疗治疗鼻咽癌有减毒增效的作用。
Objective: To observe the curative effect and side effect of Qingre Jiedu Decoction combined with radiotherapy in the treatment of nasopharyngeal carcinoma. Methods: From January 2001 to January 2004, 78 patients with advanced nasopharyngeal carcinoma were randomly divided into two groups: 39 in combination therapy group (radiotherapy + Qingrejiedu) and 39 in control group (radiotherapy alone). The two groups were divided by conventional irradiation, the target area including the primary nasopharyngeal, skull base and neck metastases. The first day of combination therapy group began to take detoxification drink, 1 / day, used to end of radiotherapy. Results: The 3 and 5-year survival rates were 82.05% and 64.10% respectively in the combined treatment group and 71.79% and 48.72% in the control group. The incidences of radioactive oropharyngeal reactions above grade Ⅰ were 25.64% and 53.84% The incidence of vaginal reaction was 7.69% and 23.07% respectively. Conclusion: There are significant differences (P <0.05) between Qingrejiedu drink and radiotherapy in the simultaneous treatment of nasopharyngeal carcinoma and radiotherapy alone, suggesting that Qingrejiedu drink combined with radiotherapy has the effect of reducing the toxicity and improving the efficiency of nasopharyngeal carcinoma.