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胃十二指肠溃疡以往多认为与消化性溃疡是同义语,目前认为由于胃溃疡与十二指肠溃疡各有不同的发病机理(前者因胃排空迟延、胆汁逆流、氢离子逆弥散、胃窦炎,后者因迷走神经功能亢进、过多胃酸进入十二指肠,消化粘膜成为溃疡),应根据解剖学部位命名较为恰当。本病应与急性和续发性溃疡区别开来,其中包括新生儿自发性溃疡以及疾病或药物引起的溃疡(如应激性溃疡、急性脑病的Cushing溃疡、大面积烧伤后的Curling溃疡、激素引起的溃疡、阿司匹林溃疡、Zollinger-Ellison综合征即非β细胞胰腺瘤,Werner综合征即多发性内分泌腺瘤Ⅰ型)等。伴随年龄的增长,原发性慢性胃十二指肠溃疡逐渐增多。
Gastroduodenal ulcers in the past and peptic ulcer is considered synonymous, now that as a result of gastric ulcer and duodenal ulcer have different pathogenesis (the former due to delayed gastric emptying, bile reflux, inverse diffusion of hydrogen ions , Antral gastritis, the latter due to vagal hyperactivity, excessive gastric acid into the duodenum, digestive mucosa become ulcers), naming appropriate anatomical sites. The disease should be distinguished from acute and persistent ulcers, including neonatal spontaneous ulceration and disease or drug-induced ulcers (eg, stress ulcer, Cushing ulcer of acute encephalopathy, Curling ulcer after extensive burn, hormone Induced ulcer, aspirin ulcer, Zollinger-Ellison syndrome ie non-beta cell pancreatic adenoma, Werner syndrome ie multiple endocrine neoplasia type I). With age, primary chronic gastroduodenal ulcer gradually increased.