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本文在离体大鼠心脏灌流模型上，比较丹参和异搏定对心脏氧反常的保护作用，结果发现用丹参（１００ｍｇ·Ｌ￣（－１））和异搏定（０．０２ｍｇ·Ｌ￣（－１））灌注都能有效地减轻心脏缺氧──复氧损伤。和氧反常组相比，二者能有效地恢复心肌收缩力（Ｐ＜０．０５）、降低再灌注心律失常发生率和心肌ＭＤＡ含量（Ｐ＜０．０１，Ｐ＜０．０５）。此外，丹参还能明显增加冠脉流量（Ｐ＜０．０１）和增加心肌组织ＳＯＤ活性（Ｐ＜０．０１）。结果提示丹参抗氧反常损伤作用较异搏定更为优越。
In this paper, isolated rat heart perfusion model to compare the protective effect of Salvia and verapamil on cardiac oxygen abnormalities and found that with Salvia (100mg · L ~ (-1)) and verapamil (0.02mg · L ~ (-1)) perfusion can effectively reduce cardiac hypoxia - reoxygenation injury. Compared with the anaerobic group, both of them could effectively restore myocardial contractility (P <0.05), reduce the incidence of reperfusion arrhythmia and myocardial MDA content (P <0.01, P <0.05). In addition, salvia miltiorrhiza also significantly increased coronary flow (P <0.01) and increased myocardial SOD activity (P <0.01). The results suggest that the anti-anoxia Danshen injury than Verapamil is more superior.