目的探讨大剂量氯磷定持续泵入治疗重度有机磷农药中毒(AOPP)的疗效。方法 45例并发呼吸衰竭的重度AOPP患者,在常规治疗的基础上采用大剂量氯磷定持续泵入治疗,直至血胆碱酯酶(ChE)活性水平>20活力单位。观察平均带机时间、3 d内撤机率、阿托品日用量、阿托品总用量、ChE活性水平恢复>20活力单位时间及ICU住院时间。结果 45例中治愈43例,治愈率95.6%,疗效满意。所有病例均无阿托品中毒,未出现明显呼吸抑制等不良反应。结论大剂量氯磷定持续泵入治疗重度有机磷农药中毒安全有效,可提高抢救成功率,缩短在ICU住院时间。 Objective To investigate the efficacy of continuous bolus injection of high-dose chlorophosphorus in the treatment of severe organophosphorus pesticide poisoning (AOPP). Methods Forty-five patients with severe AOPP complicated with respiratory failure were continuously treated with high-dose chloroprofen on a regular basis until the activity of ChE was> 20 units. The mean unit time, the withdrawal rate within 3 days, the daily dose of atropine, the total amount of atropine, the recovery of ChE activity level> 20 units of energy and ICU stay were observed. Results 45 cases were cured in 43 cases, the cure rate was 95.6%, with satisfactory results. No cases of atropine poisoning in all cases, no obvious adverse reactions such as respiratory depression. Conclusion Continuous bolus injection of high-dose chlorophosphorus into the treatment of severe organophosphorus pesticide poisoning is safe and effective, which can improve the success rate of rescue and shorten the hospital stay in ICU.