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目的:应用超临界快速膨胀技术制备中药厚朴超临界CO2流体(SCF-CO2)萃取物纳米液,并结合正交实验优选最佳工艺。方法:以平均粒径、厚朴酚、和厚朴酚的总酚含量为考察指标,采用L9(34)正交实验,对影响RESS制备厚朴纳米液的因素(萃取温度、萃取压力、喷嘴孔径、预膨胀温度)进行优选。结果:最佳制备条件为:萃取温度50℃,萃取压力25MPa,喷嘴孔径200μm,预膨胀温度30℃;此条件下得到乳白色澄清纳米液,平均粒径为303.50nm,纳米液中总酚含量为0.172g·L-1,低温密封放置1个月内仍保持稳定。结论:该技术稳定可行,且操作温度低,工艺流程简单,对环境无污染,无有机溶剂残留。
OBJECTIVE: To prepare supercritical CO2 fluid (SCF-CO2) extract nano-liquid by using supercritical rapid expansion technology and optimize the optimum technology by orthogonal experiment. Methods: With the average particle size, magnolol and honokiol content of phenol as index, using orthogonal experiment of L9 (34), the influence factors (extraction temperature, extraction pressure, Pore size, pre-expansion temperature). Results: The optimal preparation conditions were as follows: the extraction temperature was 50 ℃, the extraction pressure was 25MPa, the nozzle pore size was 200μm and the pre-expansion temperature was 30 ℃. The milky white clear nanometer liquid was obtained under this condition with the average particle size of 303.50nm. 0.172g · L-1, low temperature sealed place within 1 month remained stable. Conclusion: The technology is stable and feasible, and the operating temperature is low, the process is simple, no pollution to the environment, no organic solvent residues.