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P_(53)基因突变是肺癌中最常见的缺损基因,可能是环境致癌物起动癌症的一条途径。我们调查了高氡暴露的铀矿工人肺癌中P_(53)基因的突变。在52例大细胞癌和鳞状细胞癌中有16例(31％)发生位于密码子249的AGG到ATG的易位:其中包括从未吸烟者
The P_53 gene mutation is the most common defect gene in lung cancer and may be a pathway for cancer initiation by environmental carcinogens. We investigated the mutation of the P_53 gene in lung cancer of uranium miners exposed to sorghum. Of the 52 large cell and squamous cell carcinomas, 16 (31%) had an AGG-to-ATG translocation at codon 249: this included never-smokers.