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β-肾上腺素能阻滞剂对机体多个系统有药理效应.肝硬化时,这些系统常有严重的功能紊乱.β-阻滞剂不仅可用于治疗,且被用于研究这些复杂的病理生理改变.人们的兴趣主要集中于肾素-血管紧张素-醛固酮系统及腹水形成.α-阻滞剂抑制肾脏的肾素分泌,明显降低血浆肾素活性,但其对醛固酮的影响不一.有些患者表现为降低,有些却上升,钠的排泄也发生相应变化.因此腹水患者肾脏处理钠的异常可能与醛固酮密切相关.醛固酮增多系因肝清除率减低,可能尚有其他未知因素参与.
Beta-adrenergic blockers have pharmacological effects on multiple systems of the body, and these systems often have severe dysfunctions during cirrhosis.β-blockers are not only useful for therapy but are also used to study these complex pathophysiologies Changes.People’s interests are mainly concentrated in the renin-angiotensin-aldosterone system and the formation of ascites.α-blockers inhibit renin secretion in the kidneys, significantly reduce plasma renin activity, but its effect on aldosterone vary. Some Patients showed decreased, while some rose, sodium excretion have also changed accordingly, so patients with renal ascites renal abnormalities may be related to aldosterone is closely related to increased aldosterone due to decreased liver clearance, there may be other unknown factors involved.