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非甲非乙型肝炎病毒感染是HBV和酒精以外促成原发性肝癌(HCC)的另一个重要因素。为评估HCC的发生与HCV感染间的潜在关系,本文对不同种族和地区的一大组HCC病人作血清抗-HCV抗体检测。材料与方法:HCC病人167例(其中男135例,女32例),年龄15～72岁。其中意大利人74例,非洲人93例。153例(91.6％)有肝硬化,33人(19.7％)有嗜酒史,53例是慢性HBV感染者,3例为血清抗-HD抗体和肝内HDAg阳性者。23例在HCC确诊前至少曾输血一次。所有患者HCC的诊断均经组织学和尸解证实。实验室检查内容包括抗-HCV抗体、HBV、HAV、HDV标志物和抗CMV、EBV抗体的IgM。结果:114例HBsAg阴性的HCC病人中82例
Non-A, non-B hepatitis virus infection is another important factor contributing to primary liver cancer (HCC) other than HBV and alcohol. To assess the potential relationship between HCC occurrence and HCV infection, a panel of HCC patients from different ethnic groups and regions was tested for serum anti-HCV antibodies. Materials and Methods: 167 cases of HCC patients (135 males and 32 females), aged 15 to 72 years. 74 were Italian and 93 were African. 153 cases (91.6%) had cirrhosis, 33 (19.7%) had alcohol abuse history, 53 were chronic HBV infection, 3 were serum anti-HD antibody and intrahepatic HDAg positive. Twenty-three had at least one blood transfusion before HCC was diagnosed. The diagnosis of HCC in all patients was confirmed by histology and autopsy. Laboratory tests include anti-HCV antibodies, HBV, HAV, HDV markers and anti-CMV, EBV antibodies IgM. Results: Of the 114 HbsAg-negative patients with HCC, 82 were included