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α-干扰素(IFN)尤其淋巴母细胞干扰素(L-IFN)对阻止HBV复制和使部份慢性乙型肝炎患者病情减轻有效。α_1胸腺素(T-α_1)经临床应用证实对阻止病毒复制和改善肝功能也有一定的效果。本文作者联用IFN和T-α_1治疗慢性乙型肝炎,以评价小剂量L-IFN和T-α_1联用治疗慢性乙型肝炎的效果和对单用IFN-a2b治疗无应答的患者应用L-IFN和T-α_1联合治疗的潜在价值。
Interferon-alpha (IFN), especially lymphoblastoid interferon (L-IFN), is effective in preventing HBV replication and alleviating the condition in some chronic hepatitis B patients. α_1 thymosin (T-α_1) confirmed by clinical application to prevent viral replication and improve liver function also have some effect. The authors combined treatment of chronic hepatitis B with IFN and T-alpha-1 to evaluate the efficacy of low-dose L-IFN in combination with T-alpha-1 in the treatment of chronic hepatitis B and in patients with no response to IFN- The potential value of IFN and T-α_1 combination therapy.