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The administration of oral raloxifene in 30 postmenopausal hypertensive women was evaluated to demonstrate its effect on arterial stiffness. Casual and ambula tory blood pressure (BP)-and pulse-wave velocity(PWV) data were obtained befor e and after patients received raloxifene, estrogen-progestin replacement therap y, or placebo in a randomized crossover study. It was shown that the 2 therapies decreased BP and carotid-femo-ral PWV, and the effect of raloxifene on vascul ar compliance was independent of the effects on BP.
The administration of oral raloxifene in 30 postmenopausal hypertensive women was evaluated to demonstrate its effect on arterial stiffness. Casual and ambulant blood pressure (BP) -and pulse-wave velocity (PWV) data were obtained for and after patients received raloxifene, estrogen -progestin replacement therap y, or placebo in a randomized crossover study. It was shown that the 2 therapies decreased BP and carotid-femo-ral PWV, and the effect of raloxifene on vascul ar compliance was independent of the effects on BP.