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恶性星形细胞瘤预后不良,靶向性毒素有独特的疗效,靶向性毒素在体外对恶性星形细胞瘤有强烈细胞毒性,动物试验表明靶向性毒素可以延长生命和使肿瘤消退。临床上对软脑膜肿瘤和恶性脑瘤分别行鞘内注射和瘤内注射,结果表明靶向性毒素无明显神经毒性,脑脊液细胞学分析和放射学检查证明治疗有效。在正常脑组织和恶性肿瘤之间存在一个治疗窗,可以利用这一治疗窗施行靶向性疗法。靶向性毒素治疗恶胶质瘤具有广阔前景。
Malignant astrocytomas have poor prognosis and targeted toxins have unique therapeutic effects. Targeted toxins are highly cytotoxic to malignant astrocytomas in vitro. Animal studies have shown that targeted toxins can prolong life and regress tumors. Intrathecal injection and intratumoral injection of leptomeningeal tumor and malignant brain tumor were performed clinically. The results showed that there was no obvious neurotoxicity of targeted toxins. Cytology and radiological examination of cerebrospinal fluid proved effective. There is a therapeutic window between normal brain tissue and malignant tumors that can be used to target therapies. Targeted toxin treatment of malignant glioma has broad prospects.