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经动物实验及临床试用证实，克矽平、磷酸羟基哌喹、柠檬酸铝和汉防己甲素具有保护巨噬细胞、抑制矽性胶原化的作用。为探讨提高疗效、降低毒副反应，现提出不同或相同作用机制的药物联合用药治疗矽肺的设想。选用克矽平（气管注入）与汉防己甲素（口服）、柠檬酸铝（肌注）与磷酸羟基哌喹（口服）和汉防己甲素与磷酸羟基哌喹配合用药。联合用药组一种药物的剂量为各单独用药组的１／２，观察预防性治疗（３０～９０天）、病后治疗（９０～１８０天）及停药（９０天）后再治疗（９０天）对大鼠实验性矽肺的疗效。实验结果表明：在选用剂量条件下，各联合用药组，无论是预防性治疗还是病后治疗均表现出药效的相加作用——其疗效相当于或优于各相应单独用药组。停药后各组病变有不同程度的进展，联合用药组进展较缓；再给药后联合用药各组对病变恶化的控制作用优于相应的单独用药组。联合用药治疗矽肺的方案值得进一步讨论并推广应用
Animal experiments and clinical trials confirmed that grams of silicon, hydroxyl piperacillin, aluminum citrate and tetrandrine have the protection of macrophages, inhibition of silica collagen role. In order to explore to improve the curative effect and reduce the side effects, it is proposed that different drugs with the same mechanism of action or combination of drugs for the treatment of silicosis. Choose Ke Si Ping (tracheal injection) and tetrandrine (oral), aluminum citrate (intramuscular injection) and hydroxypaperamide (oral) and tetrandrine and hydroxylamine piperacillin medication. The combination therapy group of a drug dose for each of the separate medication group 1/2, observation of prophylactic treatment (30 to 90 days), after treatment (90 to 180 days) and withdrawal (90 days) after treatment Day) on experimental silicosis in rats. The experimental results show that, in the selected dose conditions, the combined treatment group, whether preventive or post-treatment treatment showed additive effects of the drug - the effect is equivalent to or better than the corresponding single drug group. After discontinuation of each group of lesions have varying degrees of progress, the combination group slow progress; re-administration of the combination of each group on the deterioration of the disease control is better than the corresponding single drug group. The combination of drugs for the treatment of silicosis deserves further discussion and application