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目的探讨葛根素注射液对多囊卵巢综合征大鼠胰岛素抵抗及生殖激素的影响。方法通过脱氢表雄酮诱导复制多囊卵巢综合征雌性大鼠模型92只为研究对象,随机分成两组,各46只。对照组应用二甲双胍灌胃治疗,观察组腹腔注射葛根素注射液。结果观察组总有效率84.8%,高于对照组的总有效率65.2%,差异有统计学意义(P<0.05)。干预后,观察组大鼠各项生殖激素水平均低于对照组大鼠,差异均有统计学意义(P<0.01)。干预后,观察组大鼠FINS、FPG、HOMA-IR均低于对照组大鼠,差异均有统计学意义(P<0.01)。结论葛根素注射液治疗多囊卵巢综合征疗效确切,可以调节机体生殖激素水平,改善胰岛素抵抗,促进卵巢功能的恢复。
Objective To investigate the effects of puerarin on insulin resistance and reproductive hormones in rats with polycystic ovary syndrome. METHODS: Ninety two female rats with COPD induced by dehydroepiandrosterone were randomly divided into two groups (n = 46). The control group was treated with metformin gavage, and the observation group was intraperitoneally injected with puerarin injection. Results The total effective rate of observation group was 84.8%, higher than that of control group, the total effective rate was 65.2%, the difference was statistically significant (P <0.05). After intervention, the levels of all reproductive hormones in the observation group were lower than those in the control group, with significant differences (P <0.01). After intervention, the levels of FINS, FPG and HOMA-IR in the observation group were all lower than those in the control group (P <0.01). Conclusion Puerarin injection for the treatment of polycystic ovary syndrome exact effect, can regulate the body’s reproductive hormone levels, improve insulin resistance and promote ovarian function recovery.