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目的:研究自体骨髓和脐带间充质干细胞联合移植治疗杜氏型肌营养不良(DMD)的疗效和安全性方法对经临床表现、血清酶学、肌电图、基因分析、肌肉活检、肌肉核磁共振成像(MRI)确诊的1例DMD患者采用自体骨髓和脐带间充质干细胞联合移植的方案进行治疗。术后第3、6、9、12个月定期观察患者临床症状及各项疗效指标的变化并结合国内外文献进行综合分析。结果随访12个月,该患者肌力提高,动作灵活。血清肌酸激酶和乳酸脱氢酶较前明显下降,活动能力评分和徒手肌力较前增加,肌电图运动单位电位波幅减低及时限缩短较前改善,肌肉MRI复查显示肌肉病变程度较前减轻、肌肉轮廓较前清晰。结论自体骨髓和脐带间充质干细胞联合移植是一种治疗DMD的有效治疗方法。
Objective: To study the efficacy and safety of autologous bone marrow and umbilical cord mesenchymal stem cells transplantation in the treatment of Duchenne muscular dystrophy (DMD). Methods The clinical manifestations, serum enzymes, electromyography, gene analysis, muscle biopsy, muscle magnetic resonance One case of DMD confirmed by imaging (MRI) was treated with a combination of autologous bone marrow and umbilical cord mesenchymal stem cells transplantation. The 3rd, 6th, 9th and 12th months after operation, the changes of clinical symptoms and various curative indexes were observed regularly and combined with the literature at home and abroad for comprehensive analysis. The results were followed up for 12 months, the patient increased muscle strength, flexible movements. Serum creatine kinase and lactate dehydrogenase were significantly lower than before, mobility score and hand muscle strength increased compared with the previous EMG EMF potential amplitude and shorten the duration of the previous improvement, muscle MRI review showed a lesser degree of muscle lesions than before , Muscle contour clear than before. Conclusion Autologous bone marrow and umbilical cord mesenchymal stem cells transplantation is an effective treatment for DMD.